Cathie sudlow, nicola doherty, ligia adamska, tim sprosen, rory collins, naomi e allen, comparison of sociodemographic and healthrelated characteristics of uk biobank participants with those of the general. Socioeconomic differences in healthcare use and outcomes for stroke and ischaemic heart disease in china during 200916. A full list of the icd and biobank selfreport codes used for asthma can be found in table 1 at the end of this document. It enables biobanks to manage and monitor their biological resources with efficiency. He studied pharmacology at dundee 19831987 and cambridge 19871990. Dna bank hits goal of enrolling half a million adults. Cathie sudlow and colleagues describe the uk biobank, a large populationbased prospective study, established to allow investigation of the. An open access resource for identifying the causes of. The most comprehensive health study in the uk reaches its goal of enrolling 500,000 adults. In order to address this, uk biobank was established as a prospective cohort study. N2 the uk biobank is a major uk collaborative research project to recruit and follow longitudinally the health of 500,000 volunteers aged between 4069 years. Additionally, there are a few requirements that a biobank lims software should fulfill to seamlessly handle samples and their associated information efficiently and securely. Uk biobank participants to allow more detailed assessment of certain exposures see section. Uk biobank ethics and governance council second meeting.
Extensive lifestyle and health questionnaires, a range of physical measures and collection of biological specimens are collected. Cathie sudlow and colleagues describe the uk biobank, a large populationbased prospective study, established to allow investigation of the genetic and nongenetic determinants of. The purpose of uk biobank is to set up a resource that can support a diverse range. Current status and what it means for epidemiology health policy and technology authors. Biobank software trusted by the world openspecimen. The uk biobank is a major uk collaborative research project to recruit and follow longitudinally the health of 500,000 volunteers aged between 4069 years.
It is exciting to be involved with such a large and important project that we hope, in years to come, will lead to better prevention and treatment strategies for a wide range of lifethreatening and debilitating diseases. This makes the need for biobanking software essential for these facilities so that they accurately and effectively track all information related to their samples. Tim sprosen nuffield department of population health. However, in many senses the work is just beginning as the project follows participants over time to follow their health outcomes and attempt to correlate this with genetic, clinical and environmental data already held. Tim sprosen, oxford university, david strachan, st georges university, london, cathie sudlow, uk biobank, edinburgh university. Tim sprosen, chief scientific officer for biobank, has agreed to act as advisor in this respect see section 4. Uk biobank s it and data management strategy dr tim sprosen, uk biobank 9. The uk biobank cohort is a populationbased cohort of 500,000 participants recruited in the united kingdom uk between 2006 and 2010.
Tim sprosen s 9 research works with 1,986 citations and 2,245 reads, including. Dr tim sprosen, chief scientist on the programme, spoke of his appreciation for the huge response, but stressed patience in the wait for results to emerge. Highlights uk biobank is a resource for the investigation of the determinants of a wide range of diseases. Vitalograph vitalograph spirotrac centralized spirometry.
The scope of uk biobank was extended midway through data collection to. Cathie sudlow, chief scientist, tim sprosen, steve garratt, alan young, nicola doherty, paul downey, kirsty lomas and jonathan sellers of the uk biobank staff imaging enhancement working group. We would like to acknowledge tim sprosen, alan young, sir rory collins all oxford university clinical trials service unit and epidemiological studies unit and all those who had contributed to design and development of the uk biobank eye data resource. Biobanks now play a crucial role in biomedical research by allowing for large sample volume processing and storage. Dr tim sprosen, chief scientist at uk biobank, applauded the generosity of volunteers. By putting together a vast amount of data together now. See the complete profile on linkedin and discover tim. Cathie sudlow and colleagues describe the uk biobank, a large population based prospective study, established to allow investigation of the. The mayo clinic biobank has quickly been established as a valuable resource for. But the need for reliable evidence from large randomised trials extends across all areas of medicine and trialists have applied themselves in many areas to develop this evidence. Wrexham invited to join uks biggest health study bbc news. Tim sprosen senior scientist clinical trial service.
Uk biobank and the imaging enhancement are huge team efforts. View tim sprosen s profile on linkedin, the worlds largest professional community. Bbc news biobank reaches its 500,000 volunteer target. Tim sprosen is an associate professor in the nuffield department of population health at the university of oxford. Vitalograph has proven to be an excellent development partner for uk biobank. Allen, naomi sudlow, cathie downey, paul peakman, tim danesh, john elliott, paul gallacher, john green, jane matthews, paul pell, jill sprosen, tim collins, rory journal. Linkages to diseasespecific registries and screening programs were also. Large prospective, populationbased cohorts are the optimal design for defining disease burden and studying the many. Purpose to describe the rationale, methods and research potential of eye and vision measures available in uk biobank.
Run new analyses using software provided by uk biobank. Pdf cathie sudlow and colleagues describe the uk biobank, a large populationbased prospective study, established to. He has spent his entire career in medical research in industry renal division, baxter healthcare, public office medical research council head office and. Million veteran program, a national representative and longitudinal study for genomic. If you click continue well assume that you are happy to receive all cookies and you wont see this message again. Wrexham residents are asked to join a scheme which it is hoped could help develop treatments for illnesses like cancer and heart disease.
Dr tim sprosen, uk biobank s chief scientist, said. We are going to really try and understand why it is that when some of us get to 40 and beyond we develop diseases like cancer, like heart disease. Developments in european biobanking phg foundation. When we think of large simple randomised trials we might think of maybe studies done in cardiovascular disease or cancer and testing one or more drug treatments. Participants uk biobank is a large, multisite, prospective cohort study. The uk biobank has announced that it has exceeded the original recruitment target of 500,000 individuals aged 4069. Uk biobank aims to encourage and provide as wide access as possible to its data and samples for healthrelated research in the public interest by all bona fide researchers from the academic, charity, public, and commercial sectors, both in the uk and internationally, without preferential or exclusive access for any user. January 22, 2010 natcher conference center main auditorium bethesda, maryland. By putting together a vast amount of data together now on peoples health, with the samples, we will get reliable answers to the kind of questions.
Set up and run a public campaign to make it much easier to do randomised trials in medicine. We are going to really try and understand why it is that when some of us get to 40 and beyond we develop diseases like cancer, like heart disease, like joint disease, like dementia and really understand new risk factors so that we can prevent those diseases in the first place. Definitions of asthma for uk biobank phase 1 outcomes. More information about uk biobank is also available at. Tennessee, kaiser research program on genetics, environment and health. Vitalograph spirotrac centralized spirometry system. Tdbiobank is a lims software solution for biobanking, biobanks and biorepositories. Development of uk biobank s access and intellectual property procedures 7. Manage storage locations throughout the workflow, including volume tracking and the chain of. Putting the teeth into the uk biobank sage journals. Participants health is being followed longterm, with detailed characterisation of outcomes. Cathie sudlow, john gallacher, naomi allen, valerie beral, paul burton, john danesh, paul downey, paul elliott, jane green, martin landray, bette liu, paul matthews, giok ong, jill pell, alan silman, alan young, tim sprosen.
We have already demonstrated that our joint focus on operator training and real time assessment of data has ensured high data quality in our centres, each of which see in excess of 100 people per day says dr tim sprosen, chief scientific officer at uk biobank. Tim sprosen tim peakman the uk biobank is a major uk collaborative research project to recruit and follow longitudinally the health of 500,000 volunteers aged between 4069 years. Dna bank hits goal of enrolling half a million adults bbc news. Publications nuffield department of population health. Responses will be collated and coded using the automated approaches developed in wp2.
Uk biobank is a large longterm biobank study in the united kingdom uk which is. Proposal for enhanced phenotyping of participants dr tim sprosen and mr jonathan sellors, uk biobank 8. Researchers can apply to use the data for any healthrelated research that is in the public interest. Publications from 2012 featured publications selfreported hearing loss questions provide a good measure for genetic studies. Using the rapid throughput systems developed by biobank, the enhanced, webbased questionnaire will be administered to all participants. Uk biobank opens its doors in liverpool knowsley online. Described as genomics meets epidemiology, the uk biobank is the most detailed survey in the world of middleaged people, with the intention. Biobank, biobank data management, longitudinal prospective cohort study, population research. It will provide important biological samples and environmental exposure data. Worlds biggest biobank aiming for its 500,000th deposit. The uk biobank science committee is engaged in ongoing discussions on this. Uk biobank is now open for use by all researchers worldwide.
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